
Biomarker Conference
June 21-22, 2023

Barriers & Unequal Access to Timely Molecular Testing Results:
Addressing the Inequities in Cancer Care Delays Across Canada
Addressing the Inequities in Cancer Care Delays Across Canada
Timely access to molecular testing results is an imperative healthcare issue in Canada.
The Colorectal Cancer Resource & Action Network (CCRAN) is hosting a two-day virtual conference to address the barriers and unequal access to timely molecular testing results across multiple tumour types on June 21 - 22, 2023.
Biomarker testing is vitally important in precision medicine to inform and guide treatment selection for cancer patients. Patients in Canada, however, are often at a disadvantage in terms of benefiting from targeted therapies due to delays in biomarker reporting. CCRAN has discovered that there is suboptimal patient awareness of the benefits of biomarker testing and significant variation in access to timely molecular testing results both within and between provinces.
This conference will convene clinical, policy, research and patient experts to examine the issue of timely biomarker reporting from different perspectives and across cancer types. Experts will share evidence-based insights on the challenge of timely biomarker reporting, address health system preparedness for advanced molecular testing, explore opportunities for optimizing patient care pathways through the value-based healthcare lens, and contribute to a dialogue on enablers of equitable access to biomarker testing and precision medicines.
Biomarker testing is vitally important in precision medicine to inform and guide treatment selection for cancer patients. Patients in Canada, however, are often at a disadvantage in terms of benefiting from targeted therapies due to delays in biomarker reporting. CCRAN has discovered that there is suboptimal patient awareness of the benefits of biomarker testing and significant variation in access to timely molecular testing results both within and between provinces.
This conference will convene clinical, policy, research and patient experts to examine the issue of timely biomarker reporting from different perspectives and across cancer types. Experts will share evidence-based insights on the challenge of timely biomarker reporting, address health system preparedness for advanced molecular testing, explore opportunities for optimizing patient care pathways through the value-based healthcare lens, and contribute to a dialogue on enablers of equitable access to biomarker testing and precision medicines.
Conference Agenda
Time | Session Title | Presenters/Speakers |
9:00 a.m. – 9:05 a.m. |
Conference Day 1 Opening
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Dr. Monika Slovinec D’Angelo, Ph.D. |
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Dr. Monika Slovinec D’Angelo, Ph.D. VBHC Expert, Chief Research Officer, CCRAN |
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9:05 a.m. – 9:15 a.m. |
Welcome from CCRAN’s President
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Ms. Filomena Servidio-Italiano, OCT, M.A., Ms. Emma Langelier |
Precision medicines are guided by a tumor’s biomarker status and represent a tremendous advancement in cancer treatment. They offer new hope, but systemic barriers to accessing biomarker testing and results need to be addressed. Care gaps identified by patients served as the impetus for this Conference:
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Ms. Filomena Servidio-Italiano, OCT, M.A. President & CEO, CCRAN Ms. Emma Langelier Caregiver to metastatic colorectal cancer patient |
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9:15 a.m. – 9:35 a.m. |
Why Timely Access to Molecular Testing Results is an Imperative Healthcare Issue in Canada
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Dr. Stephanie Snow, MD FRCPC |
This session will build a case for establishing practice guidelines for biomarker testing across cancer types by:
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Dr. Stephanie Snow, MD FRCPC Medical Oncologist, QEII Health Sciences Centre |
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9:35 a.m. – 10:50 a.m. |
Patient Group Roundtable: Patient Access to Precision Medicines - Molecular Testing and Timely Biomarker Reporting
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Dr. Monika Slovinec D’Angelo, Ph.D., Ms. Filomena Servidio-Italiano, OCT, M.A., Ms. Michelle Wright, Ms. Kimberly Carson, Dr. Alicia Tone, Ph.D., Dr. David Josephy, Ph.D., Ms. Kathleen Barnard, Ms. Stefanie Condon-Oldreive, Ms. Jackie Manthorne, Ms. Teresa Tiano |
This roundtable will bring together leads from patient groups across cancer types, including lung, gastric, colorectal, breast, ovarian, thyroid, pancreatic, melanoma, GIST, and blood cancers, to represent the views and experiences of cancer patients with respect to accessing biomarker testing and results in Canada. The discussion will serve to:
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Patient Group Roundtable Moderated by: Dr. Monika Slovinec D’Angelo, Ph.D., VBHC Expert, Chief Research Officer, CCRAN Colorectal Cancer: Ms. Filomena Servidio-Italiano, OCT, M.A. President & CEO, CCRAN Lung Cancer: Ms. Michelle Wright Lung Cancer Canada Breast Cancer: Ms. Kimberly Carson CEO, Breast Cancer Canada Ovarian Cancer: Dr. Alicia Tone, Ph.D. Scientific Advisor and OvCAN Project Manager, Ovarian Cancer Canada GIST: Dr. David Josephy, Ph.D. GIST Sarcoma Life Raft Group Canada Melanoma: Ms. Kathleen Barnard President, Save Your Skin Foundation Pancreatic Cancer: Ms. Stefanie Condon-Oldreive President & CEO, Craig’s Cause Pancreatic Cancer Society Rare cancers: Ms. Jackie Manthorne President & CEO, Canadian Cancer Survivor Network Gastric cancers: Ms. Teresa Tiano Chair & Co-Founder, My Gut Feeling, Stomach Cancer Foundation of Canada |
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10:50 a.m. – 11:00 a.m. |
Break
Filomena’s Recording from Lung Cancer Canada podcast |
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11:00 a.m. – 12:00 p.m. |
Facilitating Access to Precision Therapies for Colorectal Cancer, Lung Cancer, and Thyroid Cancer: Call for Timely Biomarker Reporting
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Dr. Monika Slovinec D’Angelo, Ph.D., Dr. Sharlene Gill, MD FRCPC, Dr. Shaqil Kassam, MD FRCPC, Dr. Nicole Chau, MD FRCPC, Dr. Brandon Sheffield, MD |
Clinical experts will highlight precision therapies and biomarkers relevant for each respective tumor type, and will elaborate on the importance of having biomarker testing results available during a certain timeframe in order to inform treatment decisions involving precision medicines. Delays in molecular test reporting and variations in molecular testing processes will be addressed by tumor type to inform a discussion on systemic barriers to timely access as well as opportunities for improvement across tumour types.
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Panel Session Moderated by Dr. Monika Slovinec D’Angelo, Ph.D., VBHC Expert, Chief Research Officer, CCRAN Colorectal Cancer Perspective: Dr. Sharlene Gill, MD FRCPC GI Medical Oncologist, BC Cancer Agency Lung Cancer Perspective: Dr. Shaqil Kassam, MD FRCPC Medical Oncologist, Southlake Stronach Regional Cancer Centre Thyroid Cancer Perspective: Dr. Nicole Chau, MD FRCPC Medical Oncologist, BC Cancer Agency Molecular Testing Perspective: Dr. Brandon Sheffield, MD Pathologist, William Osler Health System |
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12:00 p.m. – 1:00 p.m. |
Facilitating Access to Precision Therapies for Breast Cancer, Gastric Cancers, and GIST: Call for Timely Biomarker Reporting
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Dr. Monika Slovinec D’Angelo, Ph.D., Dr. Michael Raphael, MD FRCPC, Dr. Tim Asmis, MD FRCPC, Dr. Christine Brezden-Masley, MD PhD FRCPC, Dr. Michael Carter, MD PhD FRCPC |
Clinical experts will highlight precision therapies and biomarkers relevant for each respective tumor type, and will elaborate on the importance of having biomarker testing results available during a certain timeframe in order to inform treatment decisions involving precision medicines. Delays in molecular test reporting and variations in molecular testing processes will be addressed by tumor type to inform a discussion on systemic barriers to timely access as well as opportunities for improvement across tumour types.
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Panel Session: Moderated by Dr. Monika Slovinec D’Angelo, Ph.D., VBHC Expert, Chief Research Officer, CCRAN Gastric Cancer Perspective: Dr. Michael Raphael, MD FRCPC GI Medical Oncologist, Odette Cancer Center at Sunnybrook Health Sciences Center GIST Cancer Perspective: Dr. Tim Asmis, MD FRCPC Medical Oncologist, The Ottawa Hospital Cancer Centre Breast Cancer Perspective: Dr. Christine Brezden-Masley, MD PhD FRCPC Medical Oncologist, Mount Sinai Hospital Molecular Testing Perspective: Dr. Michael Carter, MD PhD FRCPC Pathologist, Faculty of Medicine, Dalhousie University |
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1:00 p.m. – 1:30 p.m. |
Lunch Break
Patient Video - Ms. Brenda Clayton, mother of young patient who succumbed to cholangiocarcinoma (biliary tract cancer) |
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1:30 p.m. – 2:30 p.m. |
Facilitating Access to Targeted Therapies for Gynecologic Cancers, Melanoma, and Pancreatic Cancer: Call for Timely Biomarker Reporting
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Dr. Monika Slovinec D’Angelo, Ph.D., Dr. Neesha Dhani, MD FRCPC, Dr. Patricia Tang, MD FRCPC, Dr. Eve St-Hilaire, MD FRCPC, Dr. Aaron Pollett, MD FRCPC |
Clinical experts will highlight precision therapies and biomarkers relevant for each respective tumor type, and will elaborate on the importance of having biomarker testing results available during a certain timeframe in order to inform treatment decisions involving precision medicines. Delays in molecular test reporting and variations in molecular testing processes will be addressed by tumor type to inform a discussion on systemic barriers to timely access as well as opportunities for improvement across tumour types.
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Panel Session Moderated by Dr. Monika Slovinec D’Angelo, Ph.D., VBHC Expert, Chief Research Officer, CCRAN Gynecologic Cancer Perspective: Dr. Neesha Dhani, MD FRCPC Medical oncologist, Princess Margaret Cancer Centre Pancreatic Cancer Perspective: Dr. Patricia Tang, MD FRCPC Medical Oncologist, Tom Baker Cancer Centre Melanoma Perspective: Dr. Eve St-Hilaire, MD FRCPC Medical Oncologist, Dr-Léon-Richard Oncology Centre, Vitalité Health Network Molecular Testing Perspective: Dr. Aaron Pollett, MD FRCPC Anatomic Pathologist, Division of Diagnostic Medical Genetics, Mount Sinai Hospital |
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2:30 p.m. – 3:30 p.m. |
The Forgotten and Rare Cancers: A Call to Action
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Dr. Monika Slovinec D’Angelo, Ph.D., Dr. Michael Raphael, MD FRCPC, Dr. Ravi Ramjeesingh, MD FRCPC, Dr. Shannon Jackson, MD FRCPC, Dr. Brandon Sheffield, MD FRCPC |
This session will address cancer types (e.g., hepatocellular carcinoma, cholangiocarcinoma, blood cancers, etc.) whose drug therapies are currently not guided by biomarker status. Research opportunities for identifying reliable molecular markers for several of these cancer types to predict prognosis and treatment response to precision medicines will be discussed.
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Panel Session Moderated by Dr. Monika Slovinec D’Angelo, Ph.D., VBHC Expert, Chief Research Officer, CCRAN Rare Cancer Perspective: Dr. Michael Raphael, MD FRCPC GI Medical Oncologist, Odette Cancer Center, Sunnybrook Health Sciences Center Hepatobiliary Cancer Perspective: Dr. Ravi Ramjeesingh, MD FRCPC Medical Oncologist & Associate Professor, Division of Medical Oncology, Nova Scotia Cancer Centre & Dalhousie University Chair HPB Oncology Halifax Hematology Perspective: Dr. Shannon Jackson, MD FRCPC Hematologist, West Coast Hematology, Value Based Health Care Physician Lead, Department of Hematology, Providence Health Care, St. Paul’s Hospital Molecular Testing Perspective: Dr. Brandon Sheffield, MD FRCPC Pathologist, William Osler Health System |
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3:30 p.m. – 4:30 p.m. |
The role of liquid biopsy measuring circulating tumor DNA (ctDNA) in the management of cancer
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Dr. Stephanie Snow, MD FRCPC, Mr. Rob L., Dr. Elena Tsvetkova, MD FRCPC, Dr. Minetta Liu, MD, Dr. Vincent Funari, Ph.D., Dr. Dennis Dobrovolsky, Ph.D. |
This session will address the utility of ctDNA in the management of different cancer types in both the early stage and advanced stage setting. It will provide an update on the introduction and access to ctDNA testing in Canada, through the launch of Signatera, a partnership between LifeLabs and Natera. Panel members will discuss the readiness for ctDNA testing in Canadian healthcare and the implications of having this innovative and personalized approach to diagnostic testing available to Canadians.
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Panel Session Moderated by Dr. Stephanie Snow, MD FRCPC Medical Oncologist, QEII Health Sciences Centre Cancer Patient Perspective: Mr. Rob L. Patient with lived CRC experience who accessed ctDNA testing Clinical ctDNA Expert Perspective: Dr. Elena Tsvetkova, MD FRCPC Medical Oncologist, London Health Sciences Centre, Local Principal Investigator, COBRA Study Industry Perspective: Dr. Minetta Liu, MD Chief Medical Officer, Natera Dr. Vincent Funari, Ph.D. Chief Scientific Officer, Imagia Canexia Oncology Diagnostics Laboratory Perspective: Dr. Dennis Dobrovolsky, Ph.D. Product Manager, Oncology, LifeLabs |
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4:30 p.m. – 4:45 p.m. |
Closing Remarks
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Ms. Filomena Servidio-Italiano, OCT, M.A. |
Call to action on biomarker guidance document for every tumour type.
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Ms. Filomena Servidio-Italiano, OCT, M.A. President & CEO, CCRAN |
Time | Session Title | Presenters/Speakers |
9:00 a.m. – 9:15 a.m. |
Conference Day 2 Opening & Welcome
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Dr. Monika Slovinec D’Angelo, Ph.D., Ms. Filomena Servidio-Italiano, OCT, M.A. |
Recap of Day 1 sessions:
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Dr. Monika Slovinec D’Angelo, Ph.D. VBHC Expert, Chief Research Officer, CCRAN Ms. Filomena Servidio-Italiano, OCT, M.A. President & CEO, CCRAN |
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9:15 a.m. – 10:15 a.m. |
Health System Preparedness for Advanced Biomarker Testing: Implications for Timely Access to Results
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Mr. Fred Horne, Mr. Don Husereau, Dr. Harriet Feilotter, Ph.D., Dr. Shantanu Banerji, MD FRCPC, Ms. Suzanne Wood |
This session will address key indicators of health system readiness for advanced biomarker testing in Canada and will examine:
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Panel Session Mr. Fred Horne (Moderator) Health Policy Advisor, Former Alberta Health Minister Mr. Don Husereau Health Economist, School of Medicine, University of Ottawa Dr. Harriet Feilotter, Ph.D. Molecular Geneticist, Department of Pathology and Molecular Medicine, Queens University Dr. Shantanu Banerji, MD FRCPC Medical Oncologist, CancerCare Manitoba Ms. Suzanne Wood Patient with lived CRC experience whose care was guided by ctDNA testing |
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10:15 a.m. – 11:15 a.m. |
Optimizing Patient Care Pathways through Timely Access to Biomarker Test Results
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Dr. Monika Slovinec D’Angelo, Ph.D., Dr. Durhane Wong-Rieger, Ph.D., Dr. Shannon Jackson, MD FRCPC, Dr. Ju-Yoon Yoon, MD FRCPC, Ms. Natalie Lipschultz, Ms. MJ DeCoteau |
This session will use the value-based healthcare (VBHC) framework to examine:
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Panel Session Dr. Monika Slovinec D’Angelo, Ph.D., (Moderator) VBHC Expert, Chief Research Officer, CCRAN Dr. Durhane Wong-Rieger, Ph.D. President & CEO, CORD Dr. Shannon Jackson, MD FRCPC Hematologist, West Coast Hematology, Value Based Health Care Physician Lead, Department of Hematology, Providence Health Care, St. Paul’s Hospital Dr. Ju-Yoon Yoon, MD FRCPC Molecular pathologist, St. Michael’s Hospital, Unity Health Toronto Ms. Natalie Lipschultz Patient with lived CRC experience Ms. MJ DeCoteau Founder & Executive Director, Rethink Breast Cancer HTA perspective |
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11:15 a.m. – 11:30 a.m. |
Break
Patient Video |
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11:30 a.m. – 12:30 p.m. |
“My Colorectal Cancer Consultant” - A Novel Online Tool Promoting Patient Engagement & Informed Decision Making about Therapeutic Options
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Ms. Filomena Servidio-Italiano, OCT, M.A., Dr. Mary De Vera, B.Sc., M.Sc., Ph.D. |
CCRAN’s “My Colorectal Cancer Consultant” is a user-friendly, online tool that generates potential treatment options for the metastatic patient based on the user’s tumour’s biomarker status. The recommendations generated help to promote patient engagement and informed, joint decision making around the ideal treatment setting.
The tool captures patient-reported data both nationally and internationally and this presentation will describe the tool’s objectives, utility and application to illustrate its:
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Presentation Ms. Filomena Servidio-Italiano, OCT, M.A. President & CEO, CCRAN Dr. Mary De Vera, B.Sc., M.Sc., Ph.D. Epidemiologist, Assistant Professor, University of British Columbia |
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12:30 p.m. – 1:00 p.m. |
Lunch Break
Clinician Video – Dr. Christopher Lieu, Medical Oncologist, University of Colorado Hospital |
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1:00 p.m. – 2:00 p.m. |
The Utility and Value of Comprehensive Genomic Profiling (CGP) in Cancer Care
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Dr. Monika Slovinec D’Angelo, Ph.D., Mr. Allen Chankowsky, Ms. Eva Villalba, MBA, Dr. Howard Lim, MD FRCPC, Dr. Razelle Kurzrock, MD |
The number of actionable biomarkers or genes that can inform treatment decisions is currently limited for the vast number of advanced cancer patients. CGP testing presents an opportunity to facilitate integration of precision medicine within routine cancer care, but this is contingent on enablers across the health care continuum.
This session brings together clinical, research and systems experts to elaborate on the utility and value of CGP in cancer care, showcase the work of onco-genomics programs in Canada and the U.S,. and discuss some challenges with its practical application in clinical practice. Experts will address:
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Panel Session Moderated by: Dr. Monika Slovinec D’Angelo, Ph.D., VBHC Expert, Chief Research Officer, CCRAN Cancer Patient Perspective: Mr. Allen Chankowsky Rare cancer patient with lived experience Value-Based Healthcare Perspective: Ms. Eva Villalba, MBA VBHC Expert, Executive Director, Quebec Cancer Coalition Canadian CGP Research & Program Perspective: Dr. Howard Lim, MD FRCPC Medical Oncologist, B.C. Cancer Agency U.S. CGP Research & Program Perspective: Dr. Razelle Kurzrock, MD Professor of Medicine, Associate Director of Clinical Research; Linda T. And John A. Mellowes, Chair of Precision Oncology, MCW Cancer Center & Center for Genomic Sciences and Precision Medicine; Founding Director, Michels Rare Cancers Research Laboratories, Froedtert and MCW |
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2:00 p.m. – 3:00 p.m. |
What Will it Take to Adopt Comprehensive Genomic Profiling (CGP) as a Standard of Cancer Care in Canada?
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Dr. Monika Slovinec D’Angelo, Ph.D., Dr. Cathy Eng, Dr. Marko Yurkovich, MD FRCPC, Dr. Jeffrey M. Smith, Ph.D., Dr. John L. Fox, MD MHA, Dr. Faisal M. Khan, PhD, D(ABHI) |
Genomics is transforming cancer and the field of oncology. There are some considerations, however, regarding its incorporation into routine clinical practice and expanding its benefits to patients across the country. These include infrastructural requirements related to storage, security and privacy protection of the substantial amount of data generated by NGS tests, as well as implications of secondary findings and results that are not actionable.
This session brings together experts from different disciplines to discuss these issues, the value derived from CGP testing in oncology, and strategies for accelerating its uptake in Canadian healthcare. Speakers will address:
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Panel Session Moderated by: Dr. Monika Slovinec D’Angelo, Ph.D., VBHC Expert, Chief Research Officer, CCRAN Clinical practice perspective on CGP in cancer care: Dr. Cathy Eng Medical Oncologist and Professor, Vanderbilt-Ingram Cancer Centre, Nashville, TN, U.S. Patient Perspective: Dr. Marko Yurkovich, MD FRCPC Primary care physician and stage 4 CRC patient in BC NGS Technology Perspective: Dr. Jeffrey M. Smith, Ph.D. NGS Precision Medicine Director, Clinical Next-Generation Sequencing and Oncology Division, Thermo Fisher Scientific CGP Access Perspective (U.S.): Dr. John L. Fox, MD MHA Senior Medical Director for the Americas, Market Access, Illumina CGP Access Perspective (Canada): Dr. Faisal M. Khan, PhD, D(ABHI) Director, Molecular Diagnostics, OncoHelix |
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3:00 p.m. – 3:15 p.m. |
Closing Remarks
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Ms. Filomena Servidio-Italiano, OCT, M.A. |
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Ms. Filomena Servidio-Italiano, OCT, M.A. President & CEO, CCRAN |